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General Medication Fact Sheet for Xigduo
| Field | Information |
|---|---|
| Medication Name | Xigduo |
| Generic Name | Metformin and Dapagliflozin |
| Purpose | Used to improve glycemic control in adults with type 2 diabetes mellitus, along with diet and exercise. |
| Mechanism of Action | Metformin decreases glucose production in the liver and improves insulin sensitivity. Dapagliflozin inhibits the sodium-glucose co-transporter 2 (SGLT2) in the kidneys, reducing glucose reabsorption and increasing glucose excretion. |
| Dosage Forms | Oral tablets |
| Available Strengths | Metformin/Dapagliflozin: 500mg/5mg, 500mg/10mg, 1000mg/5mg, 1000mg/10mg |
| Dosage Frequency | Typically twice daily, with meals |
| Common Side Effects | Nausea, vomiting, diarrhea, abdominal pain, genital infections (in women), urinary tract infections. |
| Serious Side Effects | Lactic acidosis, kidney problems, dehydration, ketoacidosis, serious urinary tract infections, severe allergic reactions. |
| Drug Interactions | Insulin, sulfonylureas (e.g., glipizide), diuretics, certain blood pressure medications, NSAIDs, iodinated contrast dyes. |
| Important Notes | Take with meals to reduce stomach upset. Avoid excessive alcohol consumption. Patients with kidney problems should use caution. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | Take as soon as you remember unless it is almost time for your next dose. Do not double the dose. |
| Alternatives | Metformin, Dapagliflozin (Farxiga), Empagliflozin (Jardiance), Sitagliptin (Januvia) |
Xigduo Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Metformin | Decreases glucose production in the liver and improves insulin sensitivity. | First-line treatment for type 2 diabetes. |
| Dapagliflozin (Farxiga) | Inhibits SGLT2 in the kidneys, reducing glucose reabsorption. | An SGLT2 inhibitor that can also provide cardiovascular benefits. |
| Empagliflozin (Jardiance) | Inhibits SGLT2 in the kidneys, reducing glucose reabsorption. | Another SGLT2 inhibitor with proven cardiovascular benefits. |
| Sitagliptin (Januvia) | Inhibits DPP-4, increasing incretin levels, which stimulate insulin release and decrease glucagon secretion. | A DPP-4 inhibitor that can be used as monotherapy or in combination with other diabetes medications. |
Xigduo Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Nausea | Lactic acidosis |
| Vomiting | Kidney problems |
| Diarrhea | Dehydration |
| Abdominal pain | Ketoacidosis |
| Genital infections (in women) | Serious urinary tract infections |
| Urinary tract infections | Severe allergic reactions (rash, itching, swelling, difficulty breathing) |
Xigduo Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Type 2 Diabetes | Metformin 500mg/Dapagliflozin 5mg twice daily | Individualized based on glycemic control and tolerability, up to Metformin 1000mg/Dapagliflozin 10mg twice daily | Take with meals to reduce gastrointestinal side effects. Titrate dose gradually. |
Xigduo Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $30 – $150 |
| Without Insurance (U.S.) | $850 – $900 |
| From CPS | $79.95 |
