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General Medication Fact Sheet for Xiidra
| Field | Information |
|---|---|
| Medication Name | Xiidra |
| Generic Name | Lifitegrast |
| Purpose | To treat the signs and symptoms of dry eye disease |
| Mechanism of Action | Binds to the integrin LFA-1, blocking its interaction with ICAM-1, reducing T-cell mediated inflammation in dry eye disease. |
| Dosage Forms | Ophthalmic solution (eye drops) |
| Available Strengths | 5% (50 mg/mL) |
| Dosage Frequency | One drop in each eye twice daily, approximately 12 hours apart |
| Common Side Effects | Eye irritation, discomfort, blurred vision, unusual taste sensation (dysgeusia) |
| Serious Side Effects | Severe eye pain, changes in vision, eye infection |
| Drug Interactions | No significant drug interactions reported, but consult with a healthcare provider if using other eye drops. |
| Important Notes | Remove contact lenses before using Xiidra and wait 15 minutes before reinserting them; discard single-use containers immediately after use. |
| Storage | Store at room temperature between 15°C to 25°C (59°F to 77°F) in the original foil pouch to protect from light. |
| Missed Dose | If a dose is missed, administer the drop as soon as you remember, unless it is close to the time for your next dose. Do not double the dose to catch up. |
| Alternatives | Restasis (cyclosporine), Systane (lubricant eye drops), Refresh (lubricant eye drops) |
Xiidra Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Restasis (cyclosporine) | Immunomodulator; inhibits T-cell activation and decreases inflammation. | Requires consistent use; may take several months to see full effects. |
| Systane (lubricant eye drops) | Lubricates the eye surface, providing temporary relief from dryness. | Available over-the-counter; provides symptomatic relief. |
| Refresh (lubricant eye drops) | Lubricates the eye surface, providing temporary relief from dryness. | Available over-the-counter; provides symptomatic relief. |
Xiidra Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Eye irritation | Severe eye pain |
| Eye discomfort | Changes in vision |
| Blurred vision | Eye infection |
| Unusual taste sensation (dysgeusia) | N/A |
Xiidra Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Dry Eye Disease | One drop in each eye | One drop in each eye twice daily | Administer approximately 12 hours apart; remove contact lenses before use. |
Xiidra Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $0 – $75 |
| Without Insurance (U.S.) | $750 – $900 |
| From Canada | $350 |
