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General Medication Fact Sheet for Yuflyma
| Field | Information |
|---|---|
| Medication Name | Yuflyma |
| Generic Name | Adalimumab |
| Boxed/Label Warning | Serious infections and malignancies. |
| Purpose | Tumor necrosis factor (TNF) blocker used to reduce inflammation in autoimmune diseases. |
| Mechanism of Action | Binds to TNF-alpha, preventing it from binding to its receptors and reducing inflammation. |
| Dosage Forms | Subcutaneous injection |
| Available Strengths | 40 mg/0.8 mL |
| Dosage Frequency | Varies by condition; typically every 1-2 weeks. |
| Common Side Effects | Injection site reactions (pain, swelling, redness), headache, rash. |
| Serious Side Effects | Serious infections (e.g., tuberculosis, fungal infections), lymphoma, other cancers, heart failure, nervous system disorders, allergic reactions. |
| Drug Interactions | Other TNF blockers, live vaccines, certain immunosuppressants (e.g., azathioprine, 6-mercaptopurine). |
| Important Notes | Increased risk of infection; avoid live vaccines; get tested for TB before starting treatment; monitor for signs of infection or cancer. |
| Storage | Store in the refrigerator; do not freeze. Protect from light. |
| Missed Dose | Inject the missed dose as soon as you remember, then continue your regular schedule. |
| Alternatives | Humira (adalimumab), Enbrel (etanercept), Remicade (infliximab), Cimzia (certolizumab pegol), Simponi (golimumab). |
Yuflyma Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Humira (adalimumab) | TNF-alpha inhibitor | Biosimilar alternative to Humira. |
| Enbrel (etanercept) | TNF-alpha inhibitor | Another TNF blocker used for similar conditions. |
| Remicade (infliximab) | TNF-alpha inhibitor | Administered via intravenous infusion. |
| Cimzia (certolizumab pegol) | TNF-alpha inhibitor | PEGylated TNF blocker with potentially longer duration of action. |
| Simponi (golimumab) | TNF-alpha inhibitor | Administered monthly via subcutaneous injection. |
Yuflyma Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Injection site reactions (pain, swelling, redness) | Serious infections (e.g., tuberculosis, pneumonia) |
| Headache | Lymphoma and other cancers |
| Rash | Heart failure |
| Upper respiratory infections | Nervous system disorders (e.g., multiple sclerosis-like symptoms) |
| Nausea | Allergic reactions (hives, difficulty breathing, swelling) |
Yuflyma Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Rheumatoid Arthritis | 40 mg | 40 mg every other week | May be given weekly in some patients; inject subcutaneously. |
| Psoriatic Arthritis | 40 mg | 40 mg every other week | May be given weekly in some patients; inject subcutaneously. |
| Ankylosing Spondylitis | 40 mg | 40 mg every other week | Inject subcutaneously. |
| Crohn’s Disease | 160 mg (Week 0), 80 mg (Week 2), 40 mg (Week 4) | 40 mg every other week | Inject subcutaneously. |
| Ulcerative Colitis | 160 mg (Week 0), 80 mg (Week 2), 40 mg (Week 4) | 40 mg every other week | Inject subcutaneously. |
