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Zanaflex (Tizanidine HCl)
| Tizanidine (Generic) Tizanidine Hydrochloride | ||||||
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Shipped from Canada | ||||||
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| Select product strength & quantity:
Who is the product for? YouOtherAdd Family Member/PetYou must be logged in to add additional members to the order. Don't have an account? or Add Family Member/PetSign inTo continue, please enter your email address and password that you use for your account. | ||||||
| Tizanidine (Generic) Tizanidine Hydrochloride | ||||||
Shipped from United Kingdom | ||||||
| | ||||||
| Select product strength & quantity:
Who is the product for? YouOtherAdd Family Member/PetYou must be logged in to add additional members to the order. Don't have an account? or Add Family Member/PetSign inTo continue, please enter your email address and password that you use for your account. | ||||||
| Select product strength & quantity:
Who is the product for? YouOtherAdd Family Member/PetYou must be logged in to add additional members to the order. Don't have an account? or Add Family Member/PetSign inTo continue, please enter your email address and password that you use for your account. | ||||||
General Medication Fact Sheet for Zanaflex
| Field | Information |
|---|---|
| Medication Name | Zanaflex |
| Generic Name | Tizanidine |
| Boxed/Label Warning | May cause liver damage; use with caution in patients with hepatic impairment. |
| Purpose | Muscle relaxant used to treat spasticity. |
| Mechanism of Action | Alpha-2 adrenergic agonist; reduces the release of excitatory amino acids, inhibiting spinal motor neurons. |
| Dosage Forms | Oral tablets, Oral capsules |
| Available Strengths | 2 mg, 4 mg, 6 mg (tablets); 2 mg, 4 mg (capsules) |
| Dosage Frequency | Typically every 6-8 hours as needed, not to exceed three doses in a 24-hour period. |
| Common Side Effects | Drowsiness, dizziness, dry mouth, weakness. |
| Serious Side Effects | Low blood pressure, liver damage, hallucinations. |
| Drug Interactions | CYP1A2 inhibitors (e.g., fluvoxamine, ciprofloxacin), oral contraceptives, alcohol, other CNS depressants. |
| Important Notes | Avoid alcohol; may cause significant drowsiness. Monitor liver function. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | Take as soon as you remember, unless it is almost time for your next dose. Do not double the dose. |
| Alternatives | Baclofen, Diazepam, Cyclobenzaprine, Dantrolene |
Zanaflex Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Baclofen (Lioresal) | GABA-B receptor agonist | Reduces muscle spasticity; can be administered orally or intrathecally. |
| Diazepam (Valium) | Benzodiazepine; enhances GABA-A receptor activity | Has sedative and anxiolytic effects in addition to muscle relaxation. |
| Cyclobenzaprine (Flexeril) | Centrally acting muscle relaxant | Effective for short-term relief of muscle spasms; can cause drowsiness. |
| Dantrolene (Dantrium) | Acts directly on skeletal muscle to inhibit muscle contraction | Used for severe spasticity and malignant hyperthermia. |
Zanaflex Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Drowsiness | Low blood pressure (hypotension) |
| Dizziness | Liver damage (hepatotoxicity) |
| Dry mouth | Hallucinations |
| Weakness | Fainting |
| Constipation | Slowed Heart Rate |
Zanaflex Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Spasticity | 2 mg | 2-8 mg every 6-8 hours as needed; maximum 36 mg per day | Take with or without food, but be consistent. Taking with food may increase drowsiness. |
Zanaflex Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $10 – $50 |
| Without Insurance (U.S.) | $50 – $150 |
| From CPS | $42 |
