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General Medication Fact Sheet for Zaroxolyn
| Field | Information |
|---|---|
| Medication Name | Zaroxolyn |
| Generic Name | Metolazone |
| Boxed/Label Warning | May cause electrolyte imbalances (hyponatremia, hypokalemia). Monitor electrolytes periodically. |
| Purpose | Diuretic used to treat high blood pressure and edema (fluid retention) |
| Mechanism of Action | Inhibits sodium reabsorption in the distal convoluted tubule of the kidney, leading to increased excretion of sodium and water |
| Dosage Forms | Oral tablets |
| Available Strengths | 0.5 mg, 2.5 mg, 5 mg, 10 mg |
| Dosage Frequency | Typically once daily, or as directed by a healthcare provider |
| Common Side Effects | Dizziness, lightheadedness, headache, muscle cramps, weakness, dry mouth |
| Serious Side Effects | Electrolyte imbalances (hyponatremia, hypokalemia), dehydration, hypotension, gout, hyperglycemia |
| Drug Interactions | Digoxin, lithium, corticosteroids, other diuretics, NSAIDs, insulin or oral diabetes medications |
| Important Notes | Monitor blood pressure and electrolytes regularly; take in the morning to avoid nighttime urination; use caution when standing up quickly to avoid dizziness |
| Storage | Store at room temperature away from moisture and light |
| Missed Dose | Take as soon as you remember; skip if it’s almost time for your next dose. Do not double the dose. |
| Alternatives | Hydrochlorothiazide, Furosemide, Chlorthalidone, Torsemide |
Zaroxolyn Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Hydrochlorothiazide (Microzide) | Thiazide diuretic; inhibits sodium reabsorption in the distal convoluted tubule | Commonly used for hypertension; generally well-tolerated. |
| Furosemide (Lasix) | Loop diuretic; inhibits sodium and chloride reabsorption in the loop of Henle | More potent than thiazide diuretics; used for severe edema. |
| Chlorthalidone (Thalitone) | Thiazide-like diuretic; inhibits sodium reabsorption in the distal convoluted tubule | Longer half-life compared to Hydrochlorothiazide. |
| Torsemide (Demadex) | Loop diuretic; inhibits sodium and chloride reabsorption in the loop of Henle | May have a longer duration of action than Furosemide. |
Zaroxolyn Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Dizziness | Electrolyte imbalances (hyponatremia, hypokalemia) |
| Lightheadedness | Dehydration |
| Headache | Hypotension |
| Muscle cramps | Gout |
| Weakness | Hyperglycemia |
| Dry mouth | Kidney problems |
Zaroxolyn Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Hypertension | 2.5 mg | 2.5-5 mg once daily | Take in the morning. |
| Edema | 5-20 mg | 5-20 mg once daily | Adjust dose based on response. |
| Heart Failure | 2.5 mg | 2.5-5 mg once daily | Monitor electrolytes and blood pressure. |
