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General Medication Fact Sheet for Zeldox
| Field | Information |
|---|---|
| Medication Name | Zeldox |
| Generic Name | Ziprasidone |
| Boxed/Label Warning | Increased mortality in elderly patients with dementia-related psychosis. QT prolongation and risk of torsades de pointes. |
| Purpose | Treatment of schizophrenia and acute manic or mixed episodes associated with bipolar disorder. |
| Mechanism of Action | Antagonist of dopamine D2 and serotonin 5-HT2A receptors; also inhibits serotonin and norepinephrine reuptake. |
| Dosage Forms | Oral capsules, Intramuscular injection |
| Available Strengths | 20 mg, 40 mg, 60 mg, 80 mg (capsules); 20mg/mL (injection) |
| Dosage Frequency | Typically twice daily, or as directed by a healthcare provider. |
| Common Side Effects | Drowsiness, dizziness, nausea, constipation, restlessness, extrapyramidal symptoms (EPS). |
| Serious Side Effects | Neuroleptic Malignant Syndrome (NMS), tardive dyskinesia, QT prolongation, seizures, hyperglycemia, suicidal thoughts. |
| Drug Interactions | Other drugs that prolong the QT interval (e.g., antiarrhythmics, certain antipsychotics), CNS depressants (e.g., alcohol, benzodiazepines), CYP3A4 inhibitors and inducers. |
| Important Notes | Take with food to increase absorption. Monitor for signs of NMS, tardive dyskinesia, and QT prolongation. Use caution when driving or operating machinery. |
| Storage | Store capsules at room temperature away from moisture and light. Store injection as directed. |
| Missed Dose | Take as soon as you remember, unless it is almost time for your next dose. Do not double the dose. |
| Alternatives | Risperidone (Risperdal), Quetiapine (Seroquel), Aripiprazole (Abilify), Olanzapine (Zyprexa) |
Zeldox Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Risperidone (Risperdal) | Dopamine D2 and serotonin 5-HT2A receptor antagonist | Available in oral and injectable forms. Can cause weight gain and EPS. |
| Quetiapine (Seroquel) | Dopamine D1 and D2, serotonin 5-HT1A and 5-HT2, histamine H1, and adrenergic α1 and α2 receptor antagonist | Lower risk of EPS compared to some other antipsychotics. Can cause drowsiness and weight gain. |
| Aripiprazole (Abilify) | Dopamine D2 partial agonist and serotonin 5-HT1A agonist, serotonin 5-HT2A antagonist | May have a lower risk of weight gain compared to some other antipsychotics. Can cause akathisia (restlessness). |
| Olanzapine (Zyprexa) | Dopamine D1-D4, serotonin 5-HT2A and 5-HT2C, histamine H1, adrenergic α1, and muscarinic M1-M5 receptor antagonist | Effective for acute and maintenance treatment. Higher risk of weight gain and metabolic side effects. |
Zeldox Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Drowsiness | Neuroleptic Malignant Syndrome (NMS) |
| Dizziness | Tardive Dyskinesia |
| Nausea | QT Prolongation |
| Constipation | Seizures |
| Restlessness | Hyperglycemia |
| Extrapyramidal Symptoms (EPS) | Suicidal Thoughts |
Zeldox Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Schizophrenia | 20 mg twice daily | 40-80 mg twice daily | Take with food. Adjust dose based on individual response and tolerability. |
| Bipolar Mania | 40 mg twice daily | 40-80 mg twice daily | Take with food. Adjust dose based on individual response and tolerability. |
Zeldox Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $20 – $75 |
| Without Insurance (U.S.) | $600 – $1000 |
| From Canada | $80 |
