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General Medication Fact Sheet for Zeposia
| Field | Information |
|---|---|
| Medication Name | Zeposia |
| Generic Name | Ozanimod |
| Boxed/Label Warning | May increase the risk of infections and may cause liver problems or problems during pregnancy. |
| Purpose | Used to treat relapsing forms of multiple sclerosis (MS), including clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease. |
| Mechanism of Action | A sphingosine 1-phosphate (S1P) receptor modulator, which reduces the migration of lymphocytes into the central nervous system, thereby decreasing inflammation and nerve damage in MS. |
| Dosage Forms | Oral capsules |
| Available Strengths | 0.23 mg, 0.46 mg, 0.92 mg |
| Dosage Frequency | Once daily |
| Common Side Effects | Upper respiratory tract infection, elevated liver enzymes, urinary tract infection, back pain, headache, high blood pressure. |
| Serious Side Effects | Increased risk of infections (including PML), decreased heart rate, liver damage, macular edema, posterior reversible encephalopathy syndrome (PRES), breathing problems. |
| Drug Interactions | Certain vaccines, other immunosuppressants, CYP2C8 inhibitors and inducers, strong CYP3A4 inhibitors. |
| Important Notes | Women of childbearing potential should use effective contraception during treatment and for three months after stopping. Monitor for infections and liver function. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | If a dose is missed, take it as soon as you remember. If you miss more than 1 dose in the first 14 days of treatment, contact your healthcare provider. |
| Alternatives | Gilenya (fingolimod), Aubagio (teriflunomide), Mayzent (siponimod), Tecfidera (dimethyl fumarate) |
Zeposia Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Gilenya (fingolimod) | Sphingosine 1-phosphate (S1P) receptor modulator | Similar mechanism to Zeposia, reduces lymphocyte migration. |
| Aubagio (teriflunomide) | Pyrimidine synthesis inhibitor | Reduces the proliferation of activated T and B cells. |
| Mayzent (siponimod) | Sphingosine 1-phosphate (S1P) receptor modulator | Targets S1P receptor subtypes 1 and 5. |
| Tecfidera (dimethyl fumarate) | Nrf2 activator | Has anti-inflammatory and cytoprotective properties. |
Zeposia Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Upper respiratory tract infection | Increased risk of infections (including PML) |
| Elevated liver enzymes | Decreased heart rate |
| Urinary tract infection | Liver damage |
| Back pain | Macular edema |
| Headache | Posterior reversible encephalopathy syndrome (PRES) |
| High blood pressure | Breathing problems |
Zeposia Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Relapsing Forms of Multiple Sclerosis | Day 1-4: 0.23 mg once daily; Day 5-7: 0.46 mg once daily | 0.92 mg once daily starting on Day 8 | Swallow the capsule whole; do not open, crush, or chew. |
Zeposia Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $100 – $500 |
| Without Insurance (U.S.) | $8000 – $9500 |
| From Canada | $760 |
