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Zofran (Ondansetron)
General Medication Fact Sheet for Zofran
| Field | Information |
|---|---|
| Medication Name | Zofran |
| Generic Name | Ondansetron |
| Purpose | Prevention of nausea and vomiting |
| Mechanism of Action | Blocks serotonin (5-HT3) receptors in the vomiting center of the brain and the digestive tract |
| Dosage Forms | Oral tablets, oral solution, intravenous injection |
| Available Strengths | 4 mg, 8 mg |
| Dosage Frequency | Typically three times a day, as needed or as directed by a healthcare provider |
| Common Side Effects | Headache, constipation, diarrhea, fatigue, dizziness |
| Serious Side Effects | Serotonin syndrome, abnormal heart rhythm (QT prolongation), allergic reactions |
| Drug Interactions | Other serotonin-affecting drugs (e.g., SSRIs, SNRIs), certain antiarrhythmics, tramadol |
| Important Notes | May cause dizziness; avoid driving or operating machinery until you know how this medication affects you. Consult a doctor if you have heart problems or electrolyte imbalances. |
| Storage | Store at room temperature away from moisture and light |
| Missed Dose | Take as soon as you remember; skip if it’s almost time for your next dose. Do not double the dose. |
| Alternatives | Compazine (prochlorperazine), Phenergan (promethazine), Reglan (metoclopramide), Dronabinol |
Zofran Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Compazine (prochlorperazine) | Dopamine receptor antagonist | May cause drowsiness. |
| Phenergan (promethazine) | Histamine and dopamine receptor antagonist | Can cause significant sedation. |
| Reglan (metoclopramide) | Dopamine receptor antagonist, increases gastric motility | May have long-term side effects with prolonged use. |
| Dronabinol | Cannabinoid receptor agonist | A synthetic form of THC; may cause psychoactive effects. |
Zofran Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Headache | Serotonin syndrome (agitation, hallucinations, rapid heart rate, fever) |
| Constipation | Abnormal heart rhythm (QT prolongation) |
| Diarrhea | Allergic reactions (rash, itching, swelling, difficulty breathing) |
| Fatigue | Vision changes |
| Dizziness | Seizures (rare) |
Zofran Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Chemotherapy-Induced Nausea and Vomiting | 8 mg | 8 mg every 8 hours | Start 30 minutes before chemotherapy. |
| Radiation-Induced Nausea and Vomiting | 8 mg | 8 mg every 8 hours | Administer 1-2 hours before radiation. |
| Postoperative Nausea and Vomiting | 4 mg | 4 mg every 6 hours as needed | Administer as needed. |

