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General Medication Fact Sheet for Zoladex
Dosage FormsSubcutaneous implant
| Field | Information |
|---|---|
| Medication Name | Zoladex |
| Generic Name | Goserelin |
| Purpose | Treats prostate cancer, breast cancer, endometriosis, and uterine fibroids. Also used for thinning the uterine lining before surgery. |
| Mechanism of Action | LHRH agonist; suppresses luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion, reducing sex hormone levels. |
| Available Strengths | 3.6 mg, 10.8 mg |
| Dosage Frequency | 3.6 mg: Every 28 days; 10.8 mg: Every 12 weeks, or as directed by a healthcare provider |
| Common Side Effects | Hot flashes, decreased libido, erectile dysfunction, headache, mood changes, vaginal dryness, breast tenderness |
| Serious Side Effects | Bone pain, spinal cord compression, tumor flare, ovarian cysts, hyperglycemia, changes in ECG readings |
| Drug Interactions | Antiarrhythmics (e.g., quinidine, amiodarone), medications that prolong the QT interval, other hormone therapies. |
| Important Notes | May cause temporary worsening of symptoms at the start of treatment (tumor flare); monitor blood sugar levels in diabetic patients; use effective contraception during treatment. |
| Storage | Store at room temperature. Protect from light. Keep in original packaging until use. |
| Missed Dose | Contact your doctor immediately if you miss a scheduled injection to reschedule as soon as possible. |
| Alternatives | Lupron (leuprolide), Triptorelin, Eligard (leuprolide) |
Zoladex Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Lupron (leuprolide) | LHRH agonist, similar to goserelin. | Available as injection, used for similar indications as Zoladex. |
| Eligard (leuprolide) | LHRH agonist | Injectable form used to suppress testosterone production. |
Zoladex Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Hot flashes | Bone pain |
| Decreased libido | Spinal cord compression |
| Erectile dysfunction | Tumor flare |
| Headache | Ovarian cysts |
| Mood changes | Hyperglycemia |
| Vaginal dryness | Changes in ECG readings (QT prolongation) |
| Breast tenderness | Allergic reactions (rare) |
Zoladex Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Prostate Cancer | 3.6 mg | 3.6 mg every 28 days or 10.8 mg every 12 weeks | Subcutaneous injection administered by a healthcare professional. |
| Breast Cancer | 3.6 mg | 3.6 mg every 28 days | Subcutaneous injection administered by a healthcare professional. |
| Endometriosis | 3.6 mg | 3.6 mg every 28 days | Treatment duration is usually limited to 6 months. Use effective contraception. Subcutaneous injection administered by a healthcare professional. |
| Uterine Fibroids | 3.6 mg | 3.6 mg every 28 days | Treatment duration is usually limited to 3 months. Subcutaneous injection administered by a healthcare professional. |
| Thinning of uterine lining | 3.6 mg | 3.6 mg every 28 days | Administered prior to endometrial ablation to thin the uterine lining. |
