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Zoloft (Sertraline)
| Sertraline (Generic) Sertraline | ||||||
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Shipped from Canada | ||||||
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| Sertraline (Generic) Sertraline | ||||||
Shipped from United Kingdom | ||||||
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| Sertraline (Generic) Sertraline | ||||||
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Shipped from Mauritius | ||||||
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| Sertraline Hydrochloride (Generic) Sertraline (Sertraline Hydrochloride) | ||||||
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Shipped from Canada | ||||||
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General Medication Fact Sheet for Zoloft
| Field | Information |
|---|---|
| Medication Name | Zoloft |
| Generic Name | Sertraline |
| Boxed/Label Warning | Increased risk of suicidal thoughts and behavior in children, adolescents, and young adults with major depressive disorder and other psychiatric disorders. |
| Purpose | Selective serotonin reuptake inhibitor (SSRI) antidepressant used to treat depression, obsessive-compulsive disorder (OCD), panic disorder, posttraumatic stress disorder (PTSD), social anxiety disorder, and premenstrual dysphoric disorder (PMDD). |
| Mechanism of Action | Selectively inhibits the reuptake of serotonin in the central nervous system, increasing serotonin levels in the synaptic cleft. |
| Dosage Forms | Oral tablets, Oral solution |
| Available Strengths | 25 mg, 50 mg, 100 mg |
| Dosage Frequency | Typically once daily, in the morning or evening, or as directed by a healthcare provider. |
| Common Side Effects | Nausea, diarrhea, insomnia, drowsiness, dry mouth, decreased appetite, increased sweating, sexual dysfunction. |
| Serious Side Effects | Serotonin syndrome, increased risk of bleeding, seizures, mania/hypomania, angle-closure glaucoma, hyponatremia (low sodium levels). |
| Drug Interactions | Monoamine oxidase inhibitors (MAOIs), other SSRIs, SNRIs, tricyclic antidepressants (TCAs), nonsteroidal anti-inflammatory drugs (NSAIDs), aspirin, warfarin, pimozide. |
| Important Notes | May take several weeks to experience the full therapeutic effect; do not abruptly discontinue medication; monitor for worsening of depression or suicidal thoughts, especially at the beginning of treatment or with dose changes. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | Take as soon as you remember; skip if it’s almost time for your next dose. Do not double the dose. |
| Alternatives | Lexapro (escitalopram), Prozac (fluoxetine), Paxil (paroxetine), Celexa (citalopram) |
Zoloft Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Lexapro (escitalopram) | Selective serotonin reuptake inhibitor (SSRI) | Another commonly prescribed SSRI. |
| Prozac (fluoxetine) | Selective serotonin reuptake inhibitor (SSRI) | SSRI with a longer half-life. |
| Paxil (paroxetine) | Selective serotonin reuptake inhibitor (SSRI) | SSRI that may have more anticholinergic effects. |
| Celexa (citalopram) | Selective serotonin reuptake inhibitor (SSRI) | SSRI that may have a lower risk of drug interactions. |
Zoloft Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Nausea | Serotonin Syndrome (confusion, agitation, fever, sweating, tremors) |
| Diarrhea | Increased Risk of Bleeding |
| Insomnia | Seizures |
| Drowsiness | Mania/Hypomania |
| Dry Mouth | Angle-Closure Glaucoma |
| Decreased Appetite | Hyponatremia (Low Sodium Levels) |
| Increased Sweating | Suicidal Thoughts/Behavior |
Zoloft Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Depression | 25-50 mg | 50-200 mg daily | May be taken with or without food. |
| Obsessive-Compulsive Disorder (OCD) | 25-50 mg | 50-200 mg daily | May be taken with or without food. |
| Panic Disorder | 25 mg | 50-200 mg daily | May be taken with or without food. |
| Posttraumatic Stress Disorder (PTSD) | 25 mg | 50-200 mg daily | May be taken with or without food. |
| Social Anxiety Disorder | 25 mg | 50-200 mg daily | May be taken with or without food. |
| Premenstrual Dysphoric Disorder (PMDD) | 50 mg | 50-150 mg daily | May be taken with or without food. Can be taken daily or intermittently (during the luteal phase of the menstrual cycle). |
