Notice: Images are for illustration only and may not reflect the exact product you receive. Brand-name medications may look different depending on their country of origin—Canadian versions, for example, often include a "PR" symbol on the packaging. Rest assured, the medication, dosage, and active ingredients will be exactly as prescribed. Canada Pharmacy Store is committed to your health and safety, and we work only with licensed pharmacies to ensure you receive trusted, high-quality medication every time.
Zortress (Everolimus)
| Everolimus (Generic) Everolimus | ||||||
|
Shipped from Canada | ||||||
| | ||||||
| Select product strength & quantity:
Who is the product for? YouOtherAdd Family Member/PetYou must be logged in to add additional members to the order. Don't have an account? or Add Family Member/PetSign inTo continue, please enter your email address and password that you use for your account. | ||||||
| Select product strength & quantity:
Who is the product for? YouOtherAdd Family Member/PetYou must be logged in to add additional members to the order. Don't have an account? or Add Family Member/PetSign inTo continue, please enter your email address and password that you use for your account. | ||||||
| Select product strength & quantity:
Who is the product for? YouOtherAdd Family Member/PetYou must be logged in to add additional members to the order. Don't have an account? or Add Family Member/PetSign inTo continue, please enter your email address and password that you use for your account. | ||||||
General Medication Fact Sheet for Zortress
| Field | Information |
|---|---|
| Medication Name | Zortress |
| Generic Name | Everolimus |
| Boxed/Label Warning | Increased susceptibility to infection and possible development of lymphoma and other malignancies, as well as renal thrombosis and graft loss in kidney transplant patients. Use with caution and monitor closely. |
| Purpose | An immunosuppressant used to prevent organ rejection after kidney or liver transplantation. Also used to treat some types of cancer. |
| Mechanism of Action | Inhibits mTOR (mammalian target of rapamycin), a protein kinase that regulates cell growth, proliferation, and survival. |
| Dosage Forms | Oral tablets |
| Available Strengths | 0.25 mg, 0.5 mg, 0.75 mg, 1 mg |
| Dosage Frequency | Usually once daily, consistently with or without food, or as directed by your healthcare provider. |
| Common Side Effects | Increased cholesterol, increased triglycerides, high blood pressure, anemia, swelling, nausea, diarrhea, abdominal pain, headache, fever, cough. |
| Serious Side Effects | Serious infections, kidney problems, lung problems, wound healing problems, mouth ulcers, high blood sugar, allergic reactions (rash, itching, swelling, difficulty breathing), increased risk of cancer, especially lymphoma. |
| Drug Interactions | Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, clarithromycin), strong CYP3A4 inducers (e.g., rifampin, phenytoin, carbamazepine), grapefruit and grapefruit juice, certain vaccines. |
| Important Notes | Take exactly as prescribed. Regular blood tests are required to monitor drug levels and side effects. Avoid live vaccines. Notify your doctor immediately if you develop signs of infection (e.g., fever, chills, sore throat). |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | Take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose. |
| Alternatives | Sirolimus, Tacrolimus, Cyclosporine, Mycophenolate |
Zortress Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Sirolimus (Rapamune) | mTOR inhibitor | Similar mechanism to everolimus; also used for immunosuppression. |
| Tacrolimus (Prograf, Envarsus XR) | Calcineurin inhibitor | Another commonly used immunosuppressant, works by a different mechanism. |
| Cyclosporine (Neoral, Sandimmune, Gengraf) | Calcineurin inhibitor | Another commonly used immunosuppressant, works by a different mechanism. |
| Mycophenolate (CellCept, Myfortic) | Inhibits purine synthesis | Used to suppress the immune system, often in combination with other immunosuppressants. |
Zortress Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Increased cholesterol | Serious infections |
| Increased triglycerides | Kidney problems |
| High blood pressure | Lung problems |
| Anemia | Wound healing problems |
| Swelling | Mouth ulcers |
| Nausea | Increased risk of cancer (especially lymphoma) |
| Diarrhea | Allergic reactions (rash, itching, swelling, difficulty breathing) |
| Abdominal pain | High blood sugar |
| Headache | Proteinuria |
| Fever | Renal Thrombosis |
| Cough | Graft Loss |
Zortress Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Kidney Transplant (Prevention of Organ Rejection) | 0.75 mg twice daily | Adjusted based on trough levels | Administer in combination with reduced doses of Cyclosporine; take consistently with or without food. |
| Liver Transplant (Prevention of Organ Rejection) | 1.0 mg twice daily | Adjusted based on trough levels | Administer in combination with reduced doses of Tacrolimus; take consistently with or without food. |
| Advanced Renal Cell Carcinoma | 10 mg once daily | Continue until disease progression or unacceptable toxicity | Take consistently with or without food. |
| Subependymal Giant Cell Astrocytoma (SEGA) | Varies based on BSA (Body Surface Area) | Adjusted based on trough levels | Titrate dose to achieve target trough concentrations. |
