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General Medication Fact Sheet for Zoryve
| Field | Information |
|---|---|
| Medication Name | Zoryve |
| Generic Name | Roflumilast Topical |
| Purpose | Topical phosphodiesterase-4 (PDE4) inhibitor used to treat plaque psoriasis |
| Mechanism of Action | Inhibits PDE4, reducing inflammation and improving psoriasis symptoms |
| Dosage Forms | Topical cream |
| Available Strengths | 0.3% |
| Dosage Frequency | Apply a thin layer to affected areas once daily |
| Common Side Effects | Diarrhea, headache, insomnia, nausea, application site pain |
| Serious Side Effects | Worsening of depression or suicidal thoughts |
| Drug Interactions | No known significant drug interactions with topical application; consult a healthcare provider for systemic interactions |
| Important Notes | Avoid use on broken or infected skin; consult a doctor if symptoms worsen |
| Storage | Store at room temperature away from moisture and light |
| Missed Dose | Apply as soon as you remember; skip if it’s almost time for your next dose. |
| Alternatives | Calcipotriene, Tazarotene, Topical Corticosteroids, Apremilast (Otezla) |
Zoryve Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Calcipotriene (Dovonex) | Vitamin D analog that inhibits proliferation of keratinocytes | Often used in combination with topical corticosteroids. |
| Tazarotene (Tazorac) | Topical retinoid that normalizes skin cell growth | Can be irritating to the skin. |
| Topical Corticosteroids</td> <td>Reduce inflammation and suppress immune response</td> <td>Available in various strengths; prolonged use can cause side effects.</td> </tr> <tr> <td>Apremilast (Otezla) | Oral PDE4 inhibitor for systemic treatment | Used for moderate to severe psoriasis. |
Zoryve Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Diarrhea | Worsening of depression |
| Headache | Suicidal thoughts |
| Insomnia | |
| Nausea | |
| Application Site Pain |
Zoryve Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Plaque Psoriasis | Apply a thin layer to affected areas | Apply a thin layer to affected areas once daily | Apply to clean, dry skin. Avoid contact with eyes, mouth, and other mucous membranes. |
Zoryve Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $100 – $150 |
| Without Insurance (U.S.) | $1000 – $1200 |
| From Canada | $500 |
