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General Medication Fact Sheet for Zyban
| Field | Information |
|---|---|
| Medication Name | Zyban |
| Generic Name | Bupropion Hydrochloride |
| Boxed/Label Warning | Increased risk of suicidal thinking and behavior in some individuals, especially young adults. Seizures can occur, particularly at higher doses or with predisposing risk factors. |
| Purpose | Smoking cessation aid |
| Mechanism of Action | Norepinephrine-dopamine reuptake inhibitor; exact mechanism in smoking cessation is unknown but thought to reduce cravings and withdrawal symptoms. |
| Dosage Forms | Oral tablets (extended-release) |
| Available Strengths | 150 mg |
| Dosage Frequency | Typically twice daily, with at least 8 hours between doses, or as directed by a healthcare provider. |
| Common Side Effects | Insomnia, dry mouth, nausea, headache, dizziness, anxiety, agitation. |
| Serious Side Effects | Seizures, suicidal thoughts, manic episodes, high blood pressure, allergic reactions. |
| Drug Interactions | MAOIs, other antidepressants, certain antipsychotics, antiarrhythmics, beta-blockers, CYP2B6 inhibitors/inducers, levodopa, amantadine, alcohol. |
| Important Notes | Do not use with MAOIs or if you have a seizure disorder. Use with caution if you have a history of mental health problems, high blood pressure, or heart problems. Avoid alcohol. Consult a doctor if you experience any significant side effects. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | If you miss a dose, skip it and take your next dose at the regular time. Do not double the dose. |
| Alternatives | Nicotine replacement therapies (patches, gum, lozenges), Varenicline (Chantix), Bupropion (Wellbutrin, for depression). |
Zyban Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Nicotine Patch (various brands) | Nicotine receptor agonist | Provides a controlled release of nicotine to reduce withdrawal symptoms. |
| Nicotine Gum (various brands) | Nicotine receptor agonist | Allows for on-demand nicotine release to manage cravings. |
| Varenicline (Chantix) | Partial nicotine receptor agonist | Reduces cravings and withdrawal symptoms; blocks the effects of nicotine if you smoke. |
| Bupropion (Wellbutrin) | Norepinephrine-dopamine reuptake inhibitor | Also used to treat depression, and can aid in smoking cessation. |
Zyban Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Insomnia | Seizures |
| Dry mouth | Suicidal thoughts or behaviors |
| Nausea | Manic episodes |
| Headache | High blood pressure |
| Dizziness | Allergic reactions (rash, itching, swelling, difficulty breathing) |
| Anxiety | Severe neuropsychiatric symptoms |
| Agitation | Irregular heartbeat |
Zyban Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Smoking Cessation | 150 mg once daily | 150 mg twice daily (after one week) | Start 1-2 weeks before quit date. Take with or without food. Do not crush or chew tablets. Doses should be at least 8 hours apart. Treatment duration is typically 7-12 weeks. |
Zyban Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $10 – $50 |
| Without Insurance (U.S.) | $150 – $250 |
| From CPS | $75 |
