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General Medication Fact Sheet for Zyflo CR
| Field | Information |
|---|---|
| Medication Name | Zyflo CR |
| Generic Name | Zileuton |
| Boxed/Label Warning | Liver Injury: Zileuton can cause elevated liver enzymes and, in rare cases, liver injury. Monitor liver function tests prior to initiation, periodically during treatment, and when clinically indicated. |
| Purpose | Used to prevent wheezing, shortness of breath, coughing, and chest tightness caused by asthma. |
| Mechanism of Action | A leukotriene synthesis inhibitor, specifically a 5-lipoxygenase inhibitor, which reduces the production of leukotrienes that contribute to inflammation and bronchoconstriction in asthma. |
| Dosage Forms | Extended-release oral tablets |
| Available Strengths | 600 mg |
| Dosage Frequency | Typically one tablet twice daily, within one hour after morning and evening meals. |
| Common Side Effects | Headache, nausea, diarrhea, abdominal pain, sinusitis, pharyngitis. |
| Serious Side Effects | Liver problems (elevated liver enzymes, jaundice), neuropsychiatric events (mood changes, depression, suicidal thoughts). |
| Drug Interactions | Theophylline, warfarin, propranolol. Monitor closely when co-administered. |
| Important Notes | Regular liver function tests are required. Report any signs of liver problems (e.g., jaundice, dark urine) or neuropsychiatric changes to your healthcare provider immediately. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double doses. |
| Alternatives | Montelukast (Singulair), Zafirlukast (Accolate), Inhaled Corticosteroids (e.g., Fluticasone), Combination Inhalers (e.g., Advair) |
Zyflo CR Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Montelukast (Singulair) | Leukotriene receptor antagonist | Blocks the action of leukotrienes, reducing inflammation. |
| Zafirlukast (Accolate) | Leukotriene receptor antagonist | Blocks the action of leukotrienes, reducing inflammation. |
| Inhaled Corticosteroids (e.g., Fluticasone) | Reduces inflammation in the airways | Often used as a first-line treatment for persistent asthma. |
| Combination Inhalers (e.g., Advair) | Combines an inhaled corticosteroid and a long-acting beta-agonist (LABA) | Provides both anti-inflammatory and bronchodilator effects. |
Zyflo CR Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Headache | Liver problems (elevated liver enzymes, jaundice) |
| Nausea | Neuropsychiatric events (mood changes, depression, suicidal thoughts) |
| Diarrhea | Severe allergic reactions (rash, itching, swelling, difficulty breathing) |
| Abdominal pain | Flu-like symptoms |
Zyflo CR Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Asthma | 600 mg | 600 mg twice daily | Take within one hour after morning and evening meals. Regular liver function monitoring is required. |
