| Medication Name | Zylet |
| Generic Name | Loteprednol etabonate and tobramycin |
| Purpose | Treatment of steroid-responsive inflammatory ocular conditions for which a corticosteroid is indicated and where superficial bacterial ocular infection or a risk of bacterial ocular infection exists. |
| Mechanism of Action | Loteprednol etabonate is a corticosteroid that suppresses inflammation. Tobramycin is an aminoglycoside antibiotic that inhibits bacterial protein synthesis. |
| Dosage Forms | Ophthalmic suspension (eye drops) |
| Available Strengths | Loteprednol etabonate 0.5% and tobramycin 0.3% |
| Dosage Frequency | Instill one to two drops into the affected eye(s) every four to six hours. During the initial 24 to 48 hours, the dosage may be increased to one to two drops every two hours. Frequency should be decreased gradually as warranted by improvement in clinical signs. |
| Common Side Effects | Eye irritation, increased eye pressure, burning or stinging, superficial punctate keratitis, eye itching, foreign body sensation. |
| Serious Side Effects | Secondary ocular infections (bacterial, fungal, viral), glaucoma, cataracts, delayed wound healing, optic nerve damage, visual defects. |
| Drug Interactions | Other ophthalmic medications containing corticosteroids, NSAIDs, or medications affecting liver enzymes. |
| Important Notes | Prolonged use of corticosteroids may result in glaucoma, with damage to the optic nerve, defects in visual acuity and fields of vision. Prolonged use may also suppress the host response and thus increase the hazard of secondary ocular infections. Do not use contact lenses while using Zylet. |
| Storage | Store upright at 15°-25°C (59°-77°F). Do not freeze. Protect from light. |
| Missed Dose | If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up. |
| Alternatives | Prednisolone Acetate, Dexamethasone, Tobradex (tobramycin and Dexamethasone ophthalmic suspension) |