| Medication Name | Zymaxid |
| Generic Name | Gatifloxacin |
| Boxed/Label Warning | Fluoroquinolones, including gatifloxacin, have been associated with disabling and potentially irreversible serious adverse reactions, including tendinitis and tendon rupture, peripheral neuropathy, and central nervous system effects. Discontinue immediately and avoid use of fluoroquinolones in patients who experience any of these serious adverse reactions. Reserve use for patients with no alternative treatment options for acute bacterial exacerbation of chronic bronchitis, acute uncomplicated cystitis, and acute sinusitis. |
| Purpose | Treatment of bacterial conjunctivitis |
| Mechanism of Action | Inhibits bacterial DNA gyrase and topoisomerase IV, enzymes essential for bacterial DNA replication, transcription, repair, and recombination. |
| Dosage Forms | Ophthalmic solution (eye drops) |
| Available Strengths | 0.5% (5 mg/mL) |
| Dosage Frequency | One drop in the affected eye(s) every two hours while awake on days 1 and 2, then one drop four times daily on days 3 through 7. |
| Common Side Effects | Eye irritation, burning or stinging, conjunctival hemorrhage, blurred vision, dry eye, tearing, chemosis, papillae |
| Serious Side Effects | Rarely, hypersensitivity reactions including anaphylaxis; tendon rupture (with systemic fluoroquinolones – less common with ophthalmic), Stevens-Johnson syndrome (rare) |
| Drug Interactions | No significant drug interactions reported with ophthalmic administration, but systemic absorption is possible. Use caution with other fluoroquinolones. |
| Important Notes | For ophthalmic use only. Avoid contaminating the dropper tip. Contact lenses should not be worn during treatment. |
| Storage | Store at 15-25°C (59-77°F), protect from light. |
| Missed Dose | Apply the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up. |
| Alternatives | Ciprofloxacin ophthalmic (Ciloxan), Ofloxacin ophthalmic (Ocuflox), Tobramycin ophthalmic (Tobrex), Erythromycin ophthalmic |